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RETIN-A MICRO contains tretinoin, the same active ingredient as RETIN-A and RENOVA® (tretinoin emollient cream) 0.05%. RETIN-A and RETIN-A MICRO are indicated for acne vulgaris, while RENOVA is indicated for fine wrinkles, brown spots and surface roughness when used as part of a comprehensive skin care program.
The novel acne treatment entraps tretinoin in Microsponge systems (round microscopic particles made of synthetic polymer) and formulates them into a gel. The microspheres hold the medication in reserve, allowing the skin to absorb small amounts of tretinoin over time. Dermatologists who conducted the pivotal clinical studies believe this may be why most RETIN-A MICRO patients experience little or no irritation. The microspheres themselves remain on top of the skin and are easily washed off when patients shower or wash their faces.
RETIN-A MICRO is indicated for topical application in the treatment of acne vulgaris. It is the first prescription product to use Advanced Polymer System's unique Microsponge system. This technologically-advanced system is designed to minimize the irritation commonly experienced with the highest strength of RETIN-A® (tretinoin).
RETIN-A MICRO offers the maximum strength of tretinoin with minimal irritation. It has not been compared to RETIN-A in clinical acne trials, however, clinical efficacy results appear consistent with results observed from other forms of RETIN-A . Of those using RETIN-A MICRO, 90 percent experienced no or mild erythema (redness), 84 percent experienced no or slight peeling, 88 percent experienced no or slight burning/stinging, and 91 percent experienced no or slight itching at two weeks - the typical peak irritation period for tretinoin.
RETIN-A MICRO can be applied immediately after patients wash their face, unlike RETIN-A which requires a 20-30 minute waiting period. Patients using RETIN-A MICRO should not experience the same level of skin reactions as has been seen with the higher strengths of RETIN-A in the past.
Although its exact mode of action is unknown, tretinoin is thought to loosen and expel existing acne plugs under the skin and prevent new lesions from forming. The microspheres themselves remain on top of the skin and are easily washed off when patients shower or wash their faces. RETIN-A MICRO also reduces the appearance of facial oiliness (shine) on the skin's surface.
Therapeutic results may be noticed after two weeks, but up to seven weeks of therapy may be required before consistent beneficial effects are observed. RETIN-A MICRO significantly improved patients' acne by 12 weeks in clinical studies.
In clinical studies, the RETIN-A MICRO irritation profile was found to be similar to a mild, local irritant. The most common adverse reactions to RETIN-A MICRO were limited to mild or moderate irritation of the skin. Severe cutaneous irritation occurred infrequently. Six percent of patients discontinued due to irritation. As with all topical retinoids, the skin of certain individuals may become excessively dry, red, swollen, or blistered. The manufacturer recommends application of RETIN-A MICRO once daily in the evening after washing. This product must also be used with caution in the sunlight, as it thins the stratum corneum (outermost layer of the skin), making the skin sensitive to sunlight.
Patients should avoid preparations that may dry or irritate the skin. If a reaction suggesting sensitivity or chemical irritation occurs, consult a doctor. Unprotected exposure to sunlight, including sunlamps, should be minimized and patients with sunburn should be advised not to use the product until fully recovered. Patients who are pregnant, who think they may be pregnant, or who are nursing should consult with their doctor before using this medication as no studies in pregnant women have been conducted.
Discontinue use of the product if hypersensitivity to any of the ingredients is noted.
RETIN-A MICRO is an acetone-free, alcohol-free aqueous gel with microspheres. The microspheres have an opaque powder appearance and cause the gel to look more like a cream. Its yellow appearance is primarily a result of the active ingredient, tretinoin, which is a yellow crystalline powder.
RETIN-A MICRO costs patients approximately $8-10 per month of therapy.
RETIN-A MICRO is marketed by Ortho Dermatological.
Microsponge Systems are developed by Advanced Polymer Systems, Inc.
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